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High-Stakes Science

Bad Blood: Secrets and Lies in a Silicon Valley Startup

September 8, 2018 Filed Under: Books Read

Bad Blood: Secrets and Lies in a Silicon Valley Startup

Bad Blood: Secrets and Lies in a Silicon Valley Startup by John Carreyrou
Published by Alfred A. Knopf on May 21, 2018
Pages: 341
Format: ebook
Genres: High-Stakes Science, Medicine, Nonfiction
See it @ Goodreads


Synopsis

The full inside story of the breathtaking rise and shocking collapse of a multibillion-dollar startup, by the prize-winning journalist who first broke the story and pursued it to the end in the face of pressure and threats from the CEO and her lawyers.

In 2014, Theranos founder and CEO Elizabeth Holmes was widely seen as the female Steve Jobs: a brilliant Stanford dropout whose startup "unicorn" promised to revolutionize the medical industry with a machine that would make blood tests significantly faster and easier. Backed by investors such as Larry Ellison and Tim Draper, Theranos sold shares in a fundraising round that valued the company at $9 billion, putting Holmes's worth at an estimated $4.7 billion. There was just one problem: The technology didn't work.

For years, Holmes had been misleading investors, FDA officials, and her own employees. When Carreyrou, working at The Wall Street Journal, got a tip from a former Theranos employee and started asking questions, both Carreyrou and the Journal were threatened with lawsuits. Undaunted, the newspaper ran the first of dozens of Theranos articles in late 2015. By early 2017, the company's value was zero and Holmes faced potential legal action from the government and her investors. Here is the riveting story of the biggest corporate fraud since Enron, a disturbing cautionary tale set amid the bold promises and gold-rush frenzy of Silicon Valley.

Who would have thought that a blonde haired, blue eyed nineteen-year-old drop out from Stanford University could have fooled so many, for so long? That is precisely what Elizabeth Holmes did when she incorporated her company Real-Time Cures, later renamed Theranos. By the end of 2004, Elizabeth had raised more than 6 million dollars. Before it all over Theranos had over 800 employees and a paper valuation of $9 billion. 

What happened at Theranos is a reflection of what is most common in our society today. A willingness to believe in something that can not possibly be true, a desire to follow an individual without rational thought or cause. How could someone deceive so many people for so long? What motivated Holmes to persist in this delusion? Holmes endangered thousands of lives by processing blood test without suffice blood samples. She has misled investors, terrorized employees and generally lied at every opportunity. 

This week Theranos was dissolved, it no longer exists, Elizabeth Holmes is facing criminal charges that could cost her 20 years in prison.

 

The Secret Life of Fat: The Science Behind the Body’s Least Understood Organ and What It Means for You

February 17, 2017 Filed Under: Books Read

The Secret Life of Fat: The Science Behind the Body’s Least Understood Organ and What It Means for You

The Secret Life of Fat: The Science Behind the Body's Least Understood Organ and What It Means for You by Sylvia Tara
Published by W. W. Norton & Company on December 27th 2016
Pages: 288
See it @ Goodreads


Synopsis

Fat is an obsession, a dirty word, a subject of national handwringing—and, according to biochemist Sylvia Tara, the least-understood part of our body.
You may not love your fat, but your body certainly does. In fact, your body is actually endowed with many self-defense measures to hold on to fat. For example, fat can use stem cells to regenerate; increase our appetite if it feels threatened; and use bacteria, genetics, and viruses to expand itself. The secret to losing twenty pounds? You have to work with your fat, not against it. Tara explains how your fat influences your appetite and willpower, how it defends itself when attacked, and why it grows back so quickly. The Secret Life of Fat brings cutting-edge research together with historical perspectives to reveal fat’s true identity: an endocrine organ that, in the right amount, is critical to our health. Fat triggers puberty, enables our reproductive and immune systems, and even affects brain size.
Although we spend $60 billion annually fighting fat, our efforts are often misinformed and misdirected. Tara expertly illustrates the complex role that genetics, hormones, diet, exercise, and history play in our weight, and The Secret Life of Fat sets you on the path to beat the bulge once and for all.

In Sylvia Tara’s book the The Secret Life of Fat, she discusses what some researchers have discovered about fat, she does an excellent job of describing in layperson terms how fat interacts with the body. By the end of the book, I understood that fat was very complex and it was able to effect our lives in many ways because of how it affects are bodies.

What disappointed me about the book was the way it ended, as a diet book. The author tells how she lost the 30 pounds she gained about having her third child. I think I would have enjoyed the book more if she had stuck to the science side as she did an excellent job of explaining how fat affects our bodies. I still think the book is worth reading, and recommend it because you do learn about fat and I found that fascinating.

The Death of Innocents: A True Story of Murder, Medicine, and High-Stake Science

October 21, 2016 Filed Under: Books Read

The Death of Innocents: A True Story of Murder, Medicine, and High-Stake Science

The Death of Innocents: A True Story of Murder, Medicine, and High-Stake Science by Richard Firstman, Jamie Talan
Published by Bantam on July 13th 2011
Pages: 640
See it @ Goodreads


Synopsis

Unraveling a twenty-five-year tale of multiple murder and medical deception, The Death of Innocents is a work of first-rate journalism told with the compelling narrative drive of a mystery novel. More than just a true-crime story, it is the stunning expose of spurious science that sent medical researchers in the wrong direction--and nearly allowed a murderer to go unpunished.
On July 28, 1971, a two-and-a-half-month-old baby named Noah Hoyt died in his trailer home in a rural hamlet of upstate New York. He was the fifth child of Waneta and Tim Hoyt to die suddenly in the space of seven years. People certainly talked, but Waneta spoke vaguely of "crib death," and over time the talk faded.
Nearly two decades later a district attorney in Syracuse, New York, was alerted to a landmark paper in the literature on Sudden Infant Death Syndrome--SIDS--that had been published in a prestigious medical journal back in 1972. Written by a prominent researcher at a Syracuse medical center, the article described a family in which five children had died suddenly without explanation. The D.A. was convinced that something about this account was very wrong. An intensive quest by a team of investigators came to a climax in the spring of 1995, in a dramatic multiple-murder trial that made headlines nationwide.
But this book is not only a vivid account of infanticide revealed; it is also a riveting medical detective story. That journal article had legitimized the deaths of the last two babies by theorizing a cause for the mystery of SIDS, suggesting it could be predicted and prevented, and fostering the presumption that SIDS runs in families. More than two decades of multimillion-dollar studies have failed to confirm any of these widely accepted premises. How all this happened--could have happened--is a compelling story of high-stakes medical research in action. And the enigma of familial SIDS has given rise to a special and terrible irony. There is today a maxim in forensic pathology: One unexplained infant death in a family is SIDS. Two is very suspicious. Three is homicide.
From the Trade Paperback edition.

Sometimes you just can’t make this stuff up, truth is always stranger than fiction. There are two stories in The Death of Innocents:
The first is about Dr. Alfred Steinschneider who based his clinical research on Sudden Infant Death Syndrome (SIDS) on the actions of a serial murderer. In 1970 and 1971 Waneta Hoyt lost two children, Steinschneider used these deaths to base his SIDS Research on sleep apnea as a cause of those deaths, he also indicated that it could be inherited trait. In October of 1971 Steinschneider published a paper in the Pediatrics Journal.
For the next two decades, the scientific and medical industries built a multi-million business of diagnosing SIDS as sleep apnea. Clinics were established that received generous funding from both the government and private sources, private enterprise stepped up to manufacture the home infant monitors, everyone got rich and famous but the babies kept dying.
The second story is about a prosecutor that had dealt with another suspicious SIDS death that found and doggedly followed Waneta Hoyt until he was able to bring her to justice.
The husband and wife writing team, do an excellent job of weaving the two stories together. There is no judgment in their writing, it is presented in a factual but readable way. It is an outstanding piece of investigating journalism.

Additional Links:
Wikipedia
Murderpedia

About Jamie Talan

Science writer Jamie Talan (with co-author Richard Firstman) won the 1998 Edgar Award for best nonfiction for The Death of Innocents, a gripping account of forensic science that was also a New York Times Notable Book of the Year. Talan, who covered neuroscience for Newsday for more than twenty years, is science writer-in-residence at The Feinstein Institute for Medical Research in New York.

About Richard Firstman

Richard Firstman is a former staff writer and editor at Newsday, where he was the recipient of numerous awards for feature and investigative reporting. Among his eight published books are A Criminal Injustice, a chronicle of the trial and conviction of Martin Tankleff, and The Death of Innocents, written with his wife, Jamie Talan, which was named a New York Times Notable Book of the Year and was the winner of an Edgar Award. He teaches at Stony Brook University School of Journalism and lives in Northport, New York, with his wife and their three children.

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